What a Body Carries ยท four essays
At a Glance
What are the microbes to a body? A second eater, a second set of genes, a second hand on the dial.
- 1Nothing Grows AloneWhat does a body lack when it eats alone?
- 2The One Who Stayed WellWhy does one germ take one person and pass another?
- 3A Second Hand on the DialWhat keeps the door shut, and who set normal?
- 4What the Spit Told the MilkDoes anything travel back from baby to mother?
Two eaters
Every meal feeds the body and its microbes.
- Part 1Milk sugars feed only some bacteria: every feed has two eaters.
- Part 2When fiber runs short, gut bacteria turn to the mucus coat.
- Part 3One gut makes butyrate or TMAO, depending on the meal.
- Part 4Milk carries food and seed together; the gut decides if the seed takes.
Who is already there
What a germ does depends on who already lives there.
- Part 1A probiotic label counts what goes in, not who stays.
- Part 2The same germ meets a different crowd in each body.
- Part 3Healthy mice took 100,000 Salmonella; after one antibiotic dose, fewer than three.
- Part 4In a baby's gut, one kind of Bifidobacterium usually took over.
One dose
Antibiotics hit the whole crowd, not just the germ.
- Part 1Four days of pills; six weeks to come back; nine species still gone at six months.
- Part 2Kill the butyrate makers and oxygen gets in; Salmonella and C. difficile follow.
- Part 3Protection from microbes can be lost to one dose of the wrong drug.
- Part 4Babies carried tetracycline-resistance genes, and so did the milk.
Loops both ways
Body and microbes each act on the other.
- Part 1Lose the gut microbes and the brain's seal changes.
- Part 2Bacteria feed the gut cells; the cells keep the oxygen low for them.
- Part 3Microbes may be a second hand choosing the body's targets.
- Part 4Mouth strains in milk: milk may be half of a loop.
What was counted
Keep what was measured apart from what was guessed.
- Part 1The microbiome pie shows what one project chose to study.
- Part 2Samples show who shares strains, not who passed them to whom.
- Part 3Gut bacteria predicted fever, and a link does not prove a cause.
- Part 4Two ways of reading DNA find two different crowds in milk.